Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
نویسندگان
چکیده
منابع مشابه
Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
Neutropenic conditions are prevalent in leukemia patients and are often associated with increased susceptibility to infections. In fact, emergency granulopoiesis (EG), a process regulating neutrophil homeostasis in inflammatory conditions and infections, may occur improperly in leukemic conditions, leading to reduced neutrophil counts. Unfortunately, the mechanisms central to dysfunctional EG r...
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We describe two assays to detect the action of colony-inhibiting cells. In the first assay, we used a simple density separation technique to remove dense neutrophils (PMN) from suspensions of blood and of bone marrow cells prior to culture in semisolid agar. Conditions were arranged to ensure that control suspensions of unseparated cells and test suspensions of buoyant mononuclear cells differe...
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Inhibitor of DNA binding (Id) proteins function as inhibitors of members of the basic helix-loop-helix family of transcription factors and have been demonstrated to play an important role in regulating lymphopoiesis. However, the role of these proteins in regulation of myelopoiesis is currently unclear. In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoie...
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I T IS NOW WELL ESTABLIShED that erythropoiesis is actively regulated in response to demand’ and evidence is accumulating that thrombopoiesis is ew2 A Priori reasoning and analogy suggest that granulopoiesis also is actively regulated but evidence to support this is scant. Reports by several groups of workers suggest that depletion of circulating neutrophils by means of leucapheresist or inject...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.00481